APXS is also an abbreviation for APache eXtenSion tool, an extension for Apache web servers.

An alpha particle X-ray spectrometer (APXS) is a spectrometer that analyses the chemical element composition of a sample from scattered alpha particles and fluorescent X-rays after a sample is irradiated with alpha particles and X-rays from radioactive sources. This method of analysing the elemental composition of a sample is most often used on space missions, which require low weight, small size, and minimal power consumption. Other methods (e.g. mass spectrometry) are faster, and do not require the use of radioactive materials, but require larger equipment with greater power requirements. A variation is the alpha proton X-ray spectrometer, such as on the Pathfinder mission, which also detects protons.

Over the years several modified versions of this type of instrument such as APS (without X-ray spectrometer) or APXS have been flown: Surveyor 5-7, Mars Pathfinder, Mars 96, Mars Exploration Rover, Phobos, Mars Science Laboratory and the Philae comet lander. APS/APXS devices will be included on several upcoming missions including the Chandrayaan-2 lunar rover.